Editorial: Molecular Mechanisms of Metalloid Transport, Toxicity and Tolerance

Editorial: Salinity Tolerance in Plants: Mechanisms and Regulation of Ion Transport

Editorial: The Molecular Mechanisms of Cyclic AMP in Regulation of Immunity and Tolerance

The inhibitory effects of the second messenger cyclic adenosine monophosphate (cAMP) on T-cell proliferation and effector functions have been originally reported by Gary Kammer in 1988 (1). At that time, little had been known about the mechanisms by which the inhibitory effects occur. The situation changed upon the discovery of the hallmark of cAMP responsive transcription—cAMP-responsive eleme...

Molecular Mechanisms of Pesticide Toxicity

The environment represents a key contributor to human health and disease. Exposure to many environmental stressors such as pesticides have detrimental effects on health and are considered to contribute substantially to most diseases of major public health significance. Pesticide toxicity has been clearly demonstrated to alter a variety of physiological functions. In addition, evidence suggests ...

Molecular mechanisms of fluoride toxicity.

Halfway through the twentieth century, fluoride piqued the interest of toxicologists due to its deleterious effects at high concentrations in human populations suffering from fluorosis and in in vivo experimental models. Until the 1990s, the toxicity of fluoride was largely ignored due to its "good reputation" for preventing caries via topical application and in dental toothpastes. However, in ...

Molecular mechanisms of endotoxin tolerance.

The phenomenon of endotoxin tolerance has been widely investigated, but to date, the molecular mechanisms of endotoxin tolerance remain to be resolved clearly. The discovery of the Toll-like receptor (TLR) family as the major receptors for lipopolysaccharide (LPS) and other bacterial products has prompted a resurgence of interest in endotoxin tolerance mechanisms. Changes of cell surface molecu...